The hpothetical study investigates the long-term effect of mindfulness-based stress reduction therapy (MBSR) on veterans' post-traumatic stress disorder (PTSD), compared to an active control condition (ACC). The participants (n = 102) were randomly assigned to a MBSR condition or an ACC (present-center group therapy). PTSD symptoms were measured before, directly after, and 6 months after the intervention using the Post-traumatic checklist (PCL). Expectedly, between baseline and post measurements both conditions' PCL scores significantly decreased. This decrease was significantly larger for the MBSR condition. Furthermore, at 6 months post intervention, both conditions maintained significantly lower PCL scores compared to baseline. However, between post and follow up measurements, both conditions' PCL scores increased resulting in an insignificant difference in PCL scores at follow up measurement. It was concluded that MBSR is effective in the treatment of veterans' PTSD in the long-term. Difficulties in attributing this effect to mindfulness and its exact working mechanism are discussed.